Earlier Work Research Articles

The perceived object in media-based empathy: applying Edith Stein’s concept of Wortleib

AbstractThe question of how other consciousnesses appear via media has forced us to re-think the classical phenomenological accounts of sociality. However, as the phenomenological account of empathy is very much centred around the perception of the other’s living body, it has faced challenges in discussing the empathic experience in media-based contexts, where we cannot perceive the other’s body, but something else, such as a screen or a text. In this article, I provide the concept for describing the perceived object in media-based empathy: a living textual body, based on Edith Stein’s concept of Wortleib (a living word body) referring to words as “living,” as bearers of meaning in her early work On the Problem of Empathy [Zum Problem der Einfühlung]. I divide the term Wortleib in two different cases—the empathic and non-empathic object—and thereby argue that, while the object of media-based empathic experience cannot be the other’s body, it is an empathic Wortleib, a communicative empathic object. While Stein herself discussed media-based empathy merely in paper media, I demonstrate the unique usefulness of these concepts in analysing any media-based communication and thus the timeliness of her work in this respect.

Chinese Female Writer Zhang Yueran and Fictional Features of Her Prose

In this paper, the author analyzes the fiction of contemporary Chinese female writer Zhang Yueran (b. 1982). As a radiant and influential representative of the post-1980s generation in contemporary Chinese literature, Zhang Yueran is considered to be one of most talented and strong young writers. Post-1980s Chinese writers are known by depiction of young people’s lives in big cities with elements of magical realism, however, unlike the most Post-1980s Chinese writers, Zhang Yueran focuses more on the characters’ subjectivity and their pursuit of love (parental and romantic). Her complex characters thrive for love and happiness, but also suffer from loneliness and lack of parental attention. Zhang Yueran’s writing is visceral and almost poetic in its use of metaphor. The development of Zhang Yueran’s prose can be divided two key periods. Her early works are aesthetic psychological thrillers about unhealthy love, inspired by classical fairytales that end with a character’s death and self-destruction: while the language is beautiful and almost poetic, but there is a lack of narrative depth. In her second era, Zhang Yueran returns to realism and successfully combines style and deep narrative by contrasting scenes of cruelty and mercy. At the moment her latest novel “Cocoon” embodies all significant fictional features from the perspective of both style and narrative.

Perspective: Atomistic simulations of water and aqueous systems with machine learning potentials

As the most important solvent, water has been at the center of interest since the advent of computer simulations. While early molecular dynamics and Monte Carlo simulations had to make use of simple model potentials to describe the atomic interactions, accurate ab initio molecular dynamics simulations relying on the first-principles calculation of the energies and forces have opened the way to predictive simulations of aqueous systems. Still, these simulations are very demanding, which prevents the study of complex systems and their properties. Modern machine learning potentials (MLPs) have now reached a mature state, allowing us to overcome these limitations by combining the high accuracy of electronic structure calculations with the efficiency of empirical force fields. In this Perspective, we give a concise overview about the progress made in the simulation of water and aqueous systems employing MLPs, starting from early work on free molecules and clusters via bulk liquid water to electrolyte solutions and solid–liquid interfaces.

In or out of the groove? Mechanisms of lipid scrambling by TMEM16 proteins

Phospholipid scramblases mediate the rapid movement of lipids between membrane leaflets, a key step in establishing and maintaining membrane homeostasis of the membranes of all eukaryotic cells and their organelles. Thus, impairment of lipid scrambling can lead to a variety of pathologies. How scramblases catalyzed the transbilayer movement of lipids remains poorly understood. Despite the availability of direct structural information on three unrelated families of scramblases, the TMEM16s, the Xkrs, and ATG-9, a unifying mechanism has failed to emerge thus far. Among these, the most extensively studied and best understood are the Ca2+ activated TMEM16s, which comprise ion channels and/or scramblases. Early work supported the view that these proteins provided a hydrophilic, membrane-exposed groove through which the lipid headgroups could permeate. However, structural, and functional experiments have since challenged this mechanism, leading to the proposal that the TMEM16s distort and thin the membrane near the groove to facilitate lipid scrambling. Here, we review our understanding of the structural and mechanistic underpinnings of lipid scrambling by the TMEM16s and discuss how the different proposals account for the various experimental observations.

Differential Activation of TAS2R4 May Recover Ability to Taste Propylthiouracil for Some TAS2R38 AVI Homozygotes.

Bitterness from phenylthiocarbamide and 6-n-propylthiouracil (PROP) varies with polymorphisms in the TAS2R38 gene. Three SNPs form two common (AVI, PAV) and four rare haplotypes (AAI, AAV, PVI, and PAI). AVI homozygotes exhibit higher detection thresholds and lower suprathreshold bitterness for PROP compared to PAV homozygotes and heterozygotes, and these differences may influence alcohol and vegetable intake. Within a diplotype, substantial variation in suprathreshold bitterness persists, and some AVI homozygotes report moderate bitterness at high concentrations. A second receptor encoded by a gene containing a functional polymorphism may explain this. Early work has suggested that PROP might activate TAS2R4 in vitro, but later work did not replicate this. Here, we identify three TAS2R4 SNPs that result in three diplotypes-SLN/SLN, FVS/SLN, and FVS/FVS-which make up 25.1%, 44.9%, and 23.9% of our sample. These TAS2R4 haplotypes show minimal linkage disequilibrium with TAS2R38, so we examined the suprathreshold bitterness as a function of both. The participants (n = 243) rated five PROP concentrations in duplicate, interleaved with other stimuli. As expected, the TAS2R38 haplotypes explained ~29% (p < 0.0001) of the variation in the bitterness ratings, with substantial variation within the haplotypes (AVI/AVI, PAV/AVI, and PAV/PAV). Notably, the TAS2R4 diplotypes (independent of the TAS2R38 haplotypes) explained ~7-8% of the variation in the bitterness ratings (p = 0.0001). Given this, we revisited if PROP could activate heterologously expressed TAS2R4 in HEK293T cells, and calcium imaging indicated 3 mM PROP is a weak TAS2R4 agonist. In sum, our data are consistent with the second receptor hypothesis and may explain the recovery of the PROP tasting phenotype in some AVI homozygotes; further, this finding may potentially help explain the conflicting results on the TAS2R38 diplotype and food intake.

Patriarchal Dominance in English Literature

Patriarchal dominance has been a prevalent theme in English literature throughout its history. Many literary works reflect and critique the societal norms and power structures that have historically favored men over women. Patriarchal norms prescribe rigid gender roles and expectations for men and women, reinforcing stereotypes and inequalities. Women are often relegated to traditional roles as caregivers, homemakers, and subordinate members of the family, while men are expected to be the primary breadwinners and decision-makers. These gender roles perpetuate unequal power dynamics and limit women's autonomy and agency. Prominent examples include Shakespeare's plays, where gender roles and power imbalances are often central to the plot, and classic novels like Jane Austen's "Pride and Prejudice," which explores women's limited options in a patriarchal society. Over time, literature has evolved to challenge and subvert these patriarchal norms, with authors like Virginia Woolf and Charlotte Perkins Gilman addressing issues of gender inequality and women's autonomy. Feminist literature and criticism have also played a significant role in analyzing and deconstructing patriarchal themes in English literature. Patriarchal dominance, characterized by the historical and societal power imbalance that favors men over women, has been a recurring theme in English literature throughout the ages. This theme reflects and critiques the prevailing gender norms, roles, and inequalities that have persisted within different periods and cultures of English-speaking societies. From early literary works to contemporary literature, patriarchal dominance remains a complex and enduring subject of exploration.

Ferroptosis Biology.

Ferroptosis is a regulated cell death modality triggered by iron-dependent lipid peroxidation. Ferroptosis plays a causal role in the pathophysiology of various diseases, making it a promising therapeutic target. Unlike all other cell death modalities dependent on distinct signaling cues, ferroptosis occurs when cellular antioxidative defense mechanisms fail to suppress the oxidative destruction of cellular membranes, eventually leading to cell membrane rupture. Physiologically, only two such surveillance systems are known to efficiently prevent the lipid peroxidation chain reaction by reducing (phospho)lipid hydroperoxides to their corresponding alcohols or by reducing radicals in phospholipid bilayers, thus maintaining the integrity of lipid membranes. Mechanistically, these two systems are linked to the reducing capacity of glutathione peroxidase 4 (GPX4) by consuming glutathione (GSH) on the one and ferroptosis suppressor protein 1 (FSP1, formerly AIFM2) on the other hand. Notably, the importance of ferroptosis suppression in physiological contexts has been linked to a particular vulnerability of renal tissue. In fact, early work has shown that mice genetically lacking Gpx4 rapidly succumb to acute renal failure with pathohistological features of acute tubular necrosis. Promising research attempting to implicate ferroptosis in various renal disease entities, particularly those with proximal tubular involvement, has generated a wealth of knowledge with widespread potential for clinical translation. Here, we provide a brief overview of the involvement of ferroptosis in nephrology. Our goal is to introduce this expanding field for clinically versed nephrologists in the hope of spurring future efforts to prevent ferroptosis in the pathophysiological processes of the kidney.

The journey from bench to bedside - it takes a science village.

I was fortunate enough to start my career at what was the dawn of modern-day molecular biology and to apply it to an important health problem. While my early work focused on fundamental science, the desire to understand human disease better and to find practical applications for research discoveries resulted, over the following decades, in creating a stream of translational research directed specifically towards epithelial cancers. This could only have been possible through multiple collaborations. This type of team science would eventually become a hallmark of my career. With the development of higher throughput molecular techniques, the pace of research and discovery have quickened, and the concept of personalized medicine based on genomics is now coming to fruition. I hope my legacy will not just reflect my published works, but will also include the impact I have had on the development of the next generation of scientist and clinician scientists who inspired me with their dedication, knowledge and enthusiasm.

Steven Weinberg and Higgs physics

As a tribute to Steven Weinberg, we summarize the immense impact that he had on the understanding of the mechanism of spontaneous symmetry breaking and on the physics of the Higgs boson. In particular, four landmark contributions to this field are highlighted. A first one is his early work with Goldstone and Salam on spontaneously broken continuous symmetries that paved the way to the Higgs mechanism. A second towering breakthrough is his model of leptons which later became the Standard Model of particle physics and for which he was awarded the Nobel prize with Glashow and Salam. A third seminal work is the so-called Weinberg-Linde lower bound on the Higgs boson mass that was derived from the requirement of the stability of the electroweak vacuum. Finally, we summarize his important contributions in model-building of new physics with extended Higgs sectors and their possible impact in flavor physics and CP-violation. The historical aspects as well as the contemporary way of viewing these four major topics are summarized and their impact on today Higgs physics, and more generally particle physics, is highlighted.

Ruth Barcan Marcus on the Deduction Theorem in Modal Logic

ABSTRACT In this paper, I examine Ruth Barcan Marcus's early formal work on modal systems and the deduction theorem, both for the material and the strict conditional. Marcus proved that the deduction theorem for the material conditional does not hold for system S2 but holds for S4. This last result is at odds with the recent claim that without proper restrictions the deduction theorem fails also for S4. I explain where the contrast stems from. For the strict conditional, Marcus proved the deduction theorem for S4 though restricted to arguments with necessary premises. I discuss Marcus's result and analyze her philosophical position on the significance of the deduction theorem for modal systems designed to express the notion of deducibility.

“The A.M. Kovalev’s Conception of ‘Just Society’ in the Context of Current Political and Philosophical Discussions”

In modern political and theoretical discourse, the concept of a ‘ just society’ is usually perceived as a normative idea that expresses the notion of what society “should be”. Nowadays, social justice as a political slogan is becoming an increasingly universal requirement made by social movements, political parties and groups regarding the ways of social organization and its functions. Regardless of the different interpretations, it is inseparable from other related concepts, such as ‘equality’, ‘ freedom’ and many others. It also represents the projection of various concepts of justice on social relations in individual countries, regions, and, finally, throughout the world (‘global justice’ on the scale of all mankind). Comparative analysis of the A.M. Kovalev’s concept of a just society and the main trends in the interpretation of this idea in modern Western socio-political theory indicate that the methodology developed by an outstanding Russian scientist can rightfully be considered one of the most promising. Its distinguishing feature is the creative interpretation of a set of ideas about a just society, dating back to the early works of Marx. It is combined with the analysis of the ideas of the Western European Enlightenment, the philosophy of Kant, Hegel and Fichte, the evolution of the social philosophy of the Frankfurt School and other equally influential areas of modern political theory (R. Aron and others). An analysis of modern political theories shows that the dyad “ justice / state” constitutes the ontological core of the political and philosophical discourse, in the structure of which the ideas of Marxism play an important role. In the A.M. Kovalev’s theory of a just society, the various assessments of the heuristic potential of Marxism acquire additional incentives, opening the way to new creative discussions. The article is dedicated to the 100th anniversary of the birth of A.M. Kovalev.

Natural and Engineered Guide RNA-directed Transposition with CRISPR-Associated Tn7-like Transposons.

CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated nuclease) defense systems have been naturally coopted for guide RNA-directed transposition on multiple occasions. In all cases, cooption occurred with diverse elements related to the bacterial transposon Tn7. Tn7 tightly controls transposition; the transposase is activated only when special targets are recognized by dedicated target-site selection proteins. Tn7 and the Tn7-like elements that coopted CRISPR-Cas systems evolved complementary targeting pathways: one that recognizes a highly conserved site in the chromosome and a second pathway that targets mobile plasmids capable of cell-to-cell transfer. Tn7 and Tn7-like elements deliver a single integration into the site they recognize and also control the orientation of the integration event, providing future potential for use as programmable gene-integration tools. Early work has shown that guide RNA-directed transposition systems can be adapted to diverse hosts, even within microbial communities, suggesting great potential for engineering these systems as powerful gene-editing tools.

In memoriam Prof. Dr. Dr.h.c.mult. György Jenei

Professor Dr. Dr.h.c.mult. György Jenei, the doyen of Central and Eastern European Public Administration, passed away peacefully on 4 February 2024; born in 1942, he was 82 years old. He was for many decades the leading figure of the field in our region; he personified it; he had preserved it during darker times; and he had led it again to prominence since 1989, with persistence, integrity, and style. He did so both in form and in contents – the former both at his home, Corvinus University of Budapest, and in his many leadership functions in professional and scholarly associations, including the NISPAcee Presidency during the crucial years of the Global Financial Crisis. And he truly did carry the torch of Public Administration during the times when its inefficiency was not an accident, but a core part of the local system; Professor Jenei’s early work on Max Weber was undertaken at a time when this was a politically highly incorrect thing to do.

Status and distribution of Paraguayan Procyonidae and Mephitidae (Mammalia: Carnivora)

Two species of procyonid (Nasua nasua and Procyon cancrivorus) and one species of mephitid (Conepatus chinga) have long been documented to occur in Paraguay, but very little has been published about their ecology in the country since the early 19th Century works of Azara and Rengger. Data on the distribution and status of these species in the country is collated from museum specimens, published literature and reliable observations to provide a basis for future research. A hierarchical approach is taken towards types of record and maps are provided that distinguish these for all species. All three species remain common in the Chaco region west of the Paraguay River, and all are considered of Least Concern. However, this region is experiencing high levels of deforestation and data to assess the potential declines of the species is unavailable. The two species of procyonid are also widespread in the Oriental region, but the status of Conepatus chinga there is unclear. There are multiple reports from the Atlantic Forest region but documentation is limited to fecal molecular samples. Clarifying the distribution of that species in the Oriental region is a priority for research.

Feature Engineering Versus Deep Learning for Scene Recognition: A Brief Survey

Scene recognition is an important computer vision task that has evolved from the study of the biological visual system. Its applications range from video surveillance, autopilot systems, to robotics. The early works were based on feature engineering that involved the computation and aggregation of global and local image descriptors. Several popular image features such as SIFT, SURF, HOG, ORB, LBP, KAZE, etc. have been proposed and applied to the task with successful results. Features can be either computed from the entire image on a global scale, or extracted from local sub-regions and aggregated across the image. Suitable classifier models are deployed that learn to classify these features. This review paper analyzes several of these handcrafted features that have been applied to the scene recognition task over the past decades, and tracks the transition from the traditional feature engineering to deep learning which forms the current state of the art in computer vision. Deep learning is now deemed to have overtaken feature engineering in several computer vision applications. Deep convolutional neural networks and vision transformers are the current state of the art for object recognition. However, scenes from urban landscapes are bound to contain similar objects posing a challenge to deep learning solutions for scene recognition. In our study, a critical analysis of feature engineering and deep learning methodologies for scene recognition is provided, and results on benchmark scene datasets are presented, concluding with a discussion on challenges and possible solutions that may facilitate more accurate scene recognition.

Stesk po domově a mezní situace. K Jaspersově rané recepci díla S. Kierkegaarda

The study focuses on the relationship between K. Jaspers and S. Kierkegaard. First, it evaluates the current scholarship regarding Jaspers’ reception of Kierkegaard’s thought; second, it offers an independent analysis of Jaspers’ early work (especially the 1909 Heimweh und Verbrechen, and then the Psychologie der Weltanschauungen). It is demonstrated that Jaspers’ early work on nostalgia presents the first case study of limit situations (Grenzsituationen). The paper traces the link between Kierkegaard’s conception of aesthetic existence and Jaspers’ concept of limit situations. It is shown that Jaspers’ study of nostalgia can be considered the original inspiration for the idea of limit situations, and that, at the same time, it was arguably Kierkegaard who had helped Jaspers to develop this germinal idea into a broader notion of limit situations.

Moral theology in search of a method: metaphysics or phenomenology?

The link between faith and reason, theology and philosophy is neither external nor accidental; the word logos in the name of theology rather indicates the internal connection between the two kinds of cognition. Karol Wojtyła - John Paul II is one of the few theologians of the 20th century who was proficient in the use of two philosophical languages and methods: the metaphysical and the phenomenological one. The article shows how, in his early work – the 1953 habilitation dissertation, Wojtyła reflects on the usefulness of metaphysics and phenomenology for the ethical analysis of the acting subject – crucial for both philosophical ethics and moral theology.

Impact of Interventions Supporting Girls’ Education on Early Marriage, Pregnancy and Work Participation: Evidence Synthesis

This article synthesises the evidence on the impact of interventions supporting adolescent girls’ and young women’s education on delaying marriage, childbearing and improving work participation. A total of 13 studies (eight from sub-Saharan Africa and five from South Asia) during the years 2000–2020 met our inclusion criteria. A major focus of the included studies was to reduce the schooling cost, with limited focus on strategies such as supplementary coaching, making schools girl-friendly, monitoring performance and sensitising communities about educating girls. Most studies that measured the effects on marriage and childbearing showed a positive impact. However, interventions were less successful in influencing work participation. Although a majority of studies reported positive effects on educational outcomes, fewer measured or reported positive effects on other social and health outcomes. This evidence synthesis suggests a need for studying long-term effects of such interventions on girls’ and women’s family, work and social life in order to inform policy. Studies that explore the varying impacts of such interventions on girls and women from different sociocultural settings are needed. Our evidence synthesis underscores the importance of making comprehensive efforts to support girls’ education in order to meet the global development commitments of ensuring equitable life opportunities for adolescent girls and young women.

Reassembling Visionary Physics : Donald Ault, Bruno Latour, and William Blake’s Mathematical Scenographies

Donald Ault’s work on William Blake constructs what Bruno Latour calls a scenography of a fact: an aesthetics that shifts “attention from the stage to the whole machinery of a theater.” Instead of the purified, sterile aesthetics typified by images of scientists engaged in total absorption on their object of analysis, Blake presents mathematical scenographies as visionary experiences continuously unfolding the aesthetics of fragile facts as matters of concern. Starting with his 1968 book Visionary Physics and continuing through his early unpublished work using complex variables to map the ontological transformations depicted in The Book of Urizen , this article suggests that Ault’s scholarship can be understood as a series of visionary experiments on the aesthetics and ontology of scientific facts. Ault envisions that every act of preservation in Blake’s work is also an act of transformation and becoming. As such, he anticipates later developments in Latourian lab sociology, actor-network theory (ANT), and media archaeology. Along with Latour’s pamphlet What is the Style of Matters of Concern? and its meditation on Alfred North Whitehead’s understanding of the bifurcation of nature, Ault’s mathematical scenographies provide an alternative to the neo-realist defenses of science that would reduce all experiments to acts of objectivity-making.

Voyeurism, Desire, and Narrative Subversion in Colette’s Claudine Novels

ABSTRACT This essay positions the French author Colette’s earliest works, the Claudine novels, at an inflection point in queer feminist discourses of the early 1900s. Combining recent critical explorations of the sexological and literary roots of the lesbian figure at the fin de siècle, queer theories addressing the power and limits of the heteronormative gaze, and an examination of Colette’s development of a queered authorial persona in the course of her career, I argue that the “fluffy”, “commercialized” Claudine novels in fact make use of stylistic innovation in order to subvert contemporary expectations of the lesbian narrative. Colette’s generative denial of the male gaze in her depiction of Claudine’s affair with her woman friend, Rézi, results in the adoption of a deliberately evasive, self-obliterating narrative perspective. In this, Colette anticipates later explorations of subjective desire and authorial persona in the canonically modernist works of Virginia Woolf, Radclyffe Hall, and Natalie Barney. In their exploration of the alternative modes through which an authentic desire experienced between two women might be narrativized in the twentieth century, the Claudine novels’ use of generic subversion, shifting narrative personae, and strategically fragmented prose mark them as key works in a developing sapphic modernist canon.